PhD Oral Defense, Monday, Aug 25, 2 pm: Ignacio Zuleta

Mary Tang mtang at stanford.edu
Fri Aug 22 13:16:38 PDT 2008


When: Monday 25, 2pm
Where: Clark S361
What: PhD Oral Defense

Title: A HIGH SPEED MASS SPECTROMETER BASED ON MICROMACHINED ION OPTICS AND
POSITION SENSITVE DETECTION FOR THE MONITORING OF NON-STATIONARY PROCESSES

Abstract: As new chemical systems become of relevance, the question of how
to monitor their dynamics quickly comes to the fore. In the last few years,
chemical systems consisting of complex mixtures of biological molecules have
become the subject of intense research, requiring new tools to measure their
state. Two main families of techniques have been applied extensively to
these problems, spectroscopy and mass spectrometry. With the advent of soft
ionization techniques like ESI and MALDI, proteins, DNA and metabolite
mixtures can be analyzed using mass spectrometry. Even given these
successes, the problem of continuously monitoring a condensed phase chemical
system using mass spectrometry still proves very challenging, from the
sample introduction aspect to the ability of the analyzer to monitor
efficiently the stream of ions created. We have developed a number of
advances in this regard, consisting of methods to carry over continuous mass
spectrometry based on the continuous modulation of an ion beam. These
advances consist of ion optical devices and fabrication methods for the
modulation of ion beams, novel ion detection schemes and data processing. We
show that when all these elements are combined, real-time mass spectrometric
monitoring of chemical systems at very high spectral acquisition rates can
be achieved. In particular we demonstrate its application to the monitoring
of a number of non-stationary processes: liquid plugs of a given substance,
chemical imaging of a surface and protein folding kinetics.

-- 
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
CIS Room 136, Mail Code 4070
Stanford, CA  94305
(650)723-9980
mtang at stanford.edu
http://snf.stanford.edu




More information about the labmembers mailing list