EE Ph.D. Dissertation Defense: Meredith M. Lee (Friday Nov. 11, 10AM, CIS-X Auditorium)

[Meredith M. Lee]

University Ph.D. Dissertation Defense

Department of Electrical Engineering

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*Tunable Photonic Crystal Biosensors for Portable Label-Free Diagnostics*

Meredith M. Lee

Advisor: Professor James S. Harris

Co-Advisor: Professor Shanhui Fan

Friday, November 11, 2011****

10 AM (refreshments at 9:45 AM)****

Allen (Center for Integrated Systems-X) Auditorium


Although there is a pressing global need for widely-deployable disease
detection and monitoring systems, today's options for biochemical analysis
are often bulky, slow, and expensive.  Miniaturization and integration of
devices based on micro-arrays of sources, detectors, and active or passive
biosensing surfaces provides a means to achieve handheld diagnostic
capabilities with a ‘lab-on-a-chip’.  In particular, the development of
label-free sensors offers simplified sample preparation and the opportunity
for multi-modal measurements for correlated detection.

In this talk, I will describe the design, simulation, fabrication, and
characterization of label-free sensors utilizing current-tuned and
temperature-tuned Vertical Cavity Surface Emitting Lasers (VCSELs),
integrated photodetectors, photonic crystal slab resonators, and
microfluidics.   The sensors operate in the VIS-NIR (650-850 nm) wavelength
range for low background absorption and are designed for compatibility with
previously demonstrated monolithically integrated fluorimeters.  In
addition to showing a proof-of-concept prototype for single-slab refractive
index sensing with tunable GaAs-based 670 nm VCSELs, I will present the
design, fabrication, and experimental measurement of tunable-gap coupled
photonic crystal slabs for increased flexibility and sensitivity.   These
compact, parallel sensor architectures enable multiplexed, cost-effective
on-chip biosensing, with packaged devices less than one cubic centimeter.
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