Seminar Reminder: Dr. Paul J. Hung, CellASIC Corporation 4-5pm Allen 101X

Jose Padovani josep at
Tue Jan 31 15:43:16 PST 2012

Hi all,

Interesting seminar next Tuesday, January 31, 4-5pm @ Allen 101X Auditorium.

Speaker: Dr. Paul J. Hung, CellASIC Corporation

Topic: Polymer MEMS for Cell-based Microphysiological Platform

In the post-­‐genomic era, the next waves of innovation has centered on understanding and utilizing living cells. Physiologic cells are 3D individuals receiving dynamic cues from their perspective microenvironment in order to perform properly; however, current cell-­‐based studies are dominantly conducted on static 2D format, leaving a large gap between research findings and clinical applications. Polymer Micro-­‐Electrical-­‐Mechanical Systems (MEMS) could potentially bridge the gap by providing a more clinically relevant platform to manipulate living cells. Polymer has attractive properties such as biocompatibility, gas permeability, and well-­‐ understood surface chemistry. MEMS offer the ability to probe into the time and geometric scale similar to those found in the physiologic cellular microenvironments. The established manufacturing infrastructure further reduces the level of resource investment in project development. In this talk, I will first define the roles for each component of Polymer MEMS in creating cell-­‐based microphysiological platforms. A systematic method to design physiologic-­‐ relevant cell-­‐based circuitry will then be presented. Robust manufacturing processes to implement the design on a user-­‐friendly format will be discussed. A toxicity and metabolism screening platform capable of maintaining metabolic functions of liver cells for over 4 weeks will be used as an example. Finally, potential applications of Polymer MEMS for personalized cell diagnosis and therapy will be mentioned. 

Short Bio:

Paul J Hung co-­‐founded CellASIC Corporation in 2005 to develop and commercialize advanced cell-­‐based platforms with Polymer MEMS technology. He received his B.S. degree in Electrical Engineering from National Taiwan University in 1999, and Ph.D. from University of California at Berkeley in Electrical Engineering in 2005. Dr. Hung’s research interests include polymer MEMS, biosensors, and platform engineering with the aims to develop the next generation bio-­‐ instrumentation, as well as personalized biomedical devices. 

Jose Padovani
Graduate Student
Electrical Engineering Department
Stanford University

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